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KMID : 0882420050690000934
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Korean Journal of Medicine
2005 Volume.69 No. 0 p.934 ~ p.938
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A case of refractory idiopathic thrombocytopenic purpura treated with rituximab
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Seo Suk-Min
Lim Chang-Hoon
Choi Son-Ook
Kim Hee-Je
Lee Jong-Wook
Min Woo-Sung
Kim Chun-Choo
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Abstract
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Idiopathic thrombocytopenic purpura (ITP) is an immune disorder in which platelets are opsonized by autoantibodies and prematurely destroyed by the reticuloendothelial system. Among adult patients, approximately 25～30% develop a chronic disease that will become refractory to corticosteroids and splenectomy, as well as other available agents.
Rituximab is a human-murine chimeric monoclonal antibody specific for the CD20 antigen, found on the surface of B lymphocytes. It acts via complement-dependent cytotoxicity, antibody-dependent cellular cytotoxicity, and induction of apoptosis.
We report a case of 32-year-old female with severe, refractory ITP, who presented with generalized petechiae, intractable vaginal bleeding, and pulmonary hemorrhage. After multiple conventional therapeutic trials, the patient was finally placed on weekly infusion of rituximab that resulted in a favorable response.(Korean J Med 69:S934-S938, 2005)
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KEYWORD
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Idiopathic thrombocytopenic purpura (ITP), Rituximab, Refractory
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